Article ID Journal Published Year Pages File Type
8285130 Mechanisms of Ageing and Development 2012 10 Pages PDF
Abstract
► All tested flavonoids are bioavailable to C. elegans and undergo extensive conjugation. ► Hydroxyl groups at the flavonoids B-ring and a double-bond at the C-ring promote lifespan extension. ► Hydroxyl groups at the flavonoids B-ring and a double-bond at the C-ring also reduce mtROS production and protein damage in vivo. But a causal relationship to lifespan-extension is questionable. ► The lifespan extension and mtROS reduction induced by the flavonols is DAF-16-independent.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Ageing
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