Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8285130 | Mechanisms of Ageing and Development | 2012 | 10 Pages |
Abstract
⺠All tested flavonoids are bioavailable to C. elegans and undergo extensive conjugation. ⺠Hydroxyl groups at the flavonoids B-ring and a double-bond at the C-ring promote lifespan extension. ⺠Hydroxyl groups at the flavonoids B-ring and a double-bond at the C-ring also reduce mtROS production and protein damage in vivo. But a causal relationship to lifespan-extension is questionable. ⺠The lifespan extension and mtROS reduction induced by the flavonols is DAF-16-independent.
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Authors
Gregor Grünz, Kerstin Haas, Sebastian Soukup, Martin Klingenspor, Sabine E. Kulling, Hannelore Daniel, Britta Spanier,