Article ID Journal Published Year Pages File Type
8285132 Mechanisms of Ageing and Development 2012 10 Pages PDF
Abstract
► The capacity of apoA-I and HDL to mediate cholesterol efflux is altered in Alzheimer's disease. ► This alteration is correlated with the severity of the cognitive decline. ► Alzheimer's disease-associated oxidative stress and inflammatory conditions induce an impairment of the HDL functionality.
Keywords
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Ageing
Preview
Impairment of the ABCA1 and SR-BI-mediated cholesterol efflux pathways and HDL anti-inflammatory activity in Alzheimer's disease
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