Curcumin-mediated lifespan extension in Caenorhabditis elegans

► Curcumin extends lifespan and reduced intracellular ROS and lipofuscin during aging in C. elegans. ► Curcumin affects body size and the pharyngeal pumping rate but not reproduction of wild-type C. elegans. ► Lifespan extension by curcumin in C. elegans is attributed to its antioxidative properties but not its antimicrobial properties. ► Curcumin mediated lifespan extension in C. elegans is modulated by osr-1, sek-1, mek-1, skn-1, unc-43, sir-2.1, and age-1.