| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8285249 | Mechanisms of Ageing and Development | 2011 | 7 Pages |
Abstract
⺠Extracellular signals by MMP-7 and HB-EGF are compared in young and aging HMEC. ⺠Growth signals are relayed via HB-EGF and 4ICD of the ErbB4 receptor in young HMEC. ⺠An accumulation of aging HMEC is associated with enhanced ECM formation. ⺠MMP-7 and sHB-EGF can contribute to fibrosis by cleavage of ECM compounds. ⺠Fibrosis could support EMT and growth of neoplastic cells in aging breast tissue.
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Authors
Sukhada Chaturvedi, Ralf Hass,