| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8285263 | Mechanisms of Ageing and Development | 2011 | 8 Pages |
Abstract
⺠Active Wnt-4 receptors, Fz-4 and Fz-6 are up-regulated during initialisation of thymic atrophy. ⺠Inhibitory receptor Fz-6, a negative regulator of β-catenin dependent Wnt signalling is increasingly associated with PKCδ during initialisation of thymic ageing. ⺠One of the Wnt-4 target genes is connective tissue growth factor (CTGF). ⺠CTGF, a suppressor of canonical Wnt signalling is up-regulated during ageing. ⺠Decline of the thymic epithelial network is initiated by active suppression of Wnt signalling.
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Authors
Zoltan Varecza, Krisztian Kvell, Gergely Talabér, Gyorgy Miskei, Veronika Csongei, Domokos Bartis, Graham Anderson, Eric J. Jenkinson, Judit E. Pongracz,