CHIP E3 ligase regulates mammalian senescence by modulating the levels of oxidized proteins

Article ID	Journal	Published Year	Pages	File Type
8285271	Mechanisms of Ageing and Development	2011	4 Pages	PDF

Abstract

âº CHIP modulates oxidized proteins levels and regulates mammalian senescence. âº Knockdown of CHIP induces premature senescence in HFL-1 cells. âº Cytoprotective effect of CHIP against oxidative stress in HFL-1 cells and MEFs. âº Deregulation of protein quality control in CHIPâ/â MEFs.

Keywords

Cumulative Population Doublings GFP NAC C-terminus of Hsp70-interacting protein MEFs 17AAG UFD CPDs N-acetyl-cysteine Small interfering RNA siRNA Oxidative stress Ubiquitin-proteasome system Human fibroblasts mouse embryonic fibroblasts green fluorescent protein Premature senescence CHiP UPS