Article ID Journal Published Year Pages File Type
8285274 Mechanisms of Ageing and Development 2011 11 Pages PDF
Abstract
▶ miR-34a and miR-93 are up-regulated in old rat liver. ▶ Four genes, Nrf2, Sp1, Sirt1 and Mgst1, are suppressed by miR-34a, and the latter 3 by miR-93 also. ▶ Sp1 and Nrf2 are transcription factors (TFs) for Mgst1, and the former for Sirt1 as well. ▶ A double-edged microRNA sword silences both gene messages and the TFs for their activation in aging rat liver.
Keywords
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Ageing
Preview
Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1
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