Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8285469 | Parkinsonism & Related Disorders | 2018 | 8 Pages |
Abstract
Resting-state fMRI identified marked disturbances of the overall architecture of connectivity in Parkinson's disease. The noted alterations in cortical motor areas were associated with cerebellar hyperconnectivity in early to moderately advanced stages of Parkinson's disease suggesting ongoing attempts of recovery and compensatory mechanism for affected functions. The potential to identify connectivity alterations in regions related to both motor and attentional functions requires further evaluation as an objective marker to monitor disease progression, and medical, as well as surgical interventions.
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Authors
Noora Tuovinen, Klaus Seppi, Francesco de Pasquale, Christoph Müller, Michael Nocker, Michael Schocke, Elke R. Gizewski, Christian Kremser, Gregor K. Wenning, Werner Poewe, Atbin Djamshidian, Christoph Scherfler, Morinobu Seki,