| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8285965 | Parkinsonism & Related Disorders | 2016 | 7 Pages |
Abstract
Cluster 1 and 2 seem to represent opposite ends of the PD disease stages. Patients in clusters 3 and 4 had similar age, educational level and disease duration but different symptom profiles - we therefore suggest that these clusters represent different pathways of disease progression, presumably with distinct underlying pathology localization. Future research on the neuropathophysiological characteristics of these two clusters and monitoring of disease progression is required.
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Authors
Tim D. van Balkom, Chris Vriend, Henk W. Berendse, Elisabeth M.J. Foncke, Ysbrand D. van der Werf, Odile A. van den Heuvel, Martin Klein,