Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8286009 | Parkinsonism & Related Disorders | 2016 | 24 Pages |
Abstract
Interestingly α-synuclein-aggregates, the cardinal neuropathological feature in PD, are present in both the submucosal and myenteric plexuses of the enteric nervous system, prior to their appearance in the brain, indicating a possible gut to brain route of “prion-like” spread. In this review we highlight the potential importance of gut to brain signalling in PD with particular focus on the role of the microbiota as major player in this communication.
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Authors
Valeria D. Felice, Eamonn M. Quigley, Aideen M. Sullivan, Gerard W. O'Keeffe, Siobhain M. O'Mahony,