Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8286468 | Redox Biology | 2018 | 53 Pages |
Abstract
Redox regulation has been proposed to control various aspects of carcinogenesis, cancer cell growth, metabolism, migration, invasion, metastasis and cancer vascularization. As cancer has many faces, the role of redox control in different cancers and in the numerous cancer-related processes often point in different directions. In this review, we focus on the redox control mechanisms of tumor cell destruction. The review covers the tumor-intrinsic role of oxidants derived from the reduction of oxygen and nitrogen in the control of tumor cell proliferation as well as the roles of oxidants and antioxidant systems in cancer cell death caused by traditional anticancer weapons (chemotherapeutic agents, radiotherapy, photodynamic therapy). Emphasis is also put on the role of oxidants and redox status in the outcome following interactions between cancer cells, cytotoxic lymphocytes and tumor infiltrating macrophages.
Keywords
CLLERKADCPLPOeNOSDUOXIL-2DCsKirILTHMGB1CLSGM-CSFHDCGFREGFRM-CSFMDSCMHC-IMnTBAPDDBAPE1apoptosis signal-regulated kinase 1ASK-1MAPKKKcPLAAMLCTLA-4HIF-1 αCAR-T cellsGSTIMCDDREToCTLDOXFASGSHLPSMDRGPXEGFCAFADCCDAMPapurinic/apyrimidinic endonuclease 1ATP-binding cassette transportersantibody-dependent cell-mediated cytotoxicityEtoposidedamage-associated molecular patternepithelial mesenchymal transitionendothelial NOSInterleukin-2EMTABC transportersDoxorubicinDendritic cellsmyeloid derived suppressor cellendoplasmic reticulumhypoxia inducible factor 1αepidermal growth factorgranulocyte-macrophage colony-stimulating factorcancer-associated fibroblastLOOHcytotoxic T lymphocytecytotoxic lymphocytesacute myeloid leukemiachronic lymphoid leukemialipopolysaccharidemacrophage colony-stimulating factorLipid peroxidation productsMultiple drug resistancemapLipid hydroperoxidehistamine dihydrochlorideDNA damage responsemitogen-activated proteincytotoxic T-lymphocyte-associated protein 4mitogen-activated protein kinase kinase kinaseHigh mobility group box 1extracellular signal-regulated kinaseGlutathioneGlutathione transferaseglutathione peroxidaseHuman estrogen receptorkiller immunoglobulin-like receptorGrowth factor receptorEpidermal growth factor receptor
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Authors
Csaba Hegedűs, Katalin Kovács, Zsuzsanna Polgár, Zsolt Regdon, Ãva Szabó, Agnieszka Robaszkiewicz, Henry Jay Forman, Anna Martner, László Virág,