| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8286518 | Redox Biology | 2018 | 25 Pages |
Abstract
Oxysterols generated by autoxidation (but not enzymatically) were elevated up to 45 fold in hypercholesterolaemic midlife men. Plasma oxysterols were restored to those of healthy controls after simvastatin intervention suggesting that autoxidation is either prevented by simvastatin directly or that autoxidation is less prevalent when plasma cholesterol concentrations are within the normal range.
Keywords
25-OHCCXPoxLDLMRMSPECH25HBHT24S-OHCLLOQ27-OHCESI7-KC24S-hydroxycholesterol25-Hydroxycholesterol27-Hydroxycholesterol7-Ketocholesterol7β-hydroxycholesterolLC-MS/MSenzyme linked immunosorbent assayApoeapolipoprotein EStatinSolid phase extractionstandard deviationcollision energyAlzheimer's diseaseVascular diseaseELISADementiastandard errorCoefficient of VariationMass spectrometryLiquid chromatography mass spectrometryOxidised low density lipoproteinbutylated hydroxytoluenehydroxycholesteroldeclustering potentialGas chromatographyCholesterol 25-hydroxylasequality control
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Authors
Irundika H.K. Dias, Ivana Milic, Gregory Y.H. Lip, Andrew Devitt, M. Cristina Polidori, Helen R. Griffiths,