| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8286530 | Redox Biology | 2018 | 38 Pages |
Abstract
Ripk3 was strongly upregulated in murine hearts subjected to IR injury and cardiomyocytes treated with LPS and H2O2. The upregulated Ripk3 may evoke the ER stress, which was accompanied with intracellular calcium overload and XO expression. Activated XO raised cellular reactive oxygen species (ROS) that mediated the mPTP and cardiomyocytes necroptosis.269
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Authors
Pingjun Zhu, Shunying Hu, Qinhua Jin, Dandan Li, Feng Tian, Sam Toan, Yang Li, Hao Zhou, Yundai Chen,