Cardioprotection of CAPE-oNO2 against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and in vitro

The Cardioprotection of CAPE-oNO2against MIRI via the SIRT1/ eNOS / NF-κB pathway. CAPE-oNO2 ameliorated MIRI by suppressing the oxidative stress, inflammatory response, fibrosis and necrocytosis via the SIRT1/ eNOS / NF-κB pathway. IR, ischemia/reperfusion; HR, hypoxia/reoxygenation; L-NAME, eNOS inhibitor Nω-nitro-L-arginine methyl ester; NAM, SIRT1 inhibitor nicotinamide; CAPE, caffeic acid phenethyl ester; oNO2, caffeic acid o-nitro phenethyl ester.186