MicroRNA-140-5p aggravates doxorubicin-induced cardiotoxicity by promoting myocardial oxidative stress via targeting Nrf2 and Sirt2

Article ID	Journal	Published Year	Pages	File Type
8286621	Redox Biology	2018	13 Pages	PDF

Keywords

NQO1 RT-PCR HO-1 DAPI GST GSH PMSF FOXO3a Nrf2 Heme oxygenase-1 ncRNA GCLM SIRT2 TRIS DOX SDS miR-140-5p MDA keap1 GSH-Px H&E MTT NAD(P)H quinone dehydrogenase 1 non-coding RNAs ROS Oxidative damage Electrocardiograms ECG forkhead box O3 Doxorubicin SOD sodium dodecyl sulfate Cardiotoxicity Superoxide dismutase antioxidant response element Phenylmethanesulfonyl fluoride lactate dehydrogenase LDH malondialdehyde ARE hematoxylin-eosin Creatine kinase glutamate-cysteine ligase modifier subunit Glutathione glutathione peroxidase Reactive oxygen species

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Ageing

MicroRNA-140-5p aggravates doxorubicin-induced cardiotoxicity by promoting myocardial oxidative stress via targeting Nrf2 and Sirt2

Authors

Lisha Zhao, Yan Qi, Lina Xu, Xufeng Tao, Xu Han, Lianhong Yin, Jinyong Peng,