Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8286707 | Redox Biology | 2018 | 12 Pages |
Abstract
Association of oxidative stress with carcinogenesis is well known, but not understood well, as is pathophysiology of oxidative stress generated during different types of anti-cancer treatments. Moreover, recent findings indicate that cancer associated lipid peroxidation might eventually help defending adjacent nonmalignant cells from cancer invasion. Therefore, untargeted metabolomics studies designed for advanced translational and clinical studies are needed to understand the existing paradoxes in oncology, including those related to controversial usage of antioxidants aiming to prevent or treat cancer. In this short review we have tried to put emphasis on the importance of pathophysiology of oxidative stress and lipid peroxidation in cancer development in relation to metabolic adaptation of particular types of cancer allowing us to conclude that adaptation to oxidative stress is one of the main driving forces of cancer pathophysiology. With the help of metabolomics many novel findings are being achieved thus encouraging further scientific breakthroughs. Combined with targeted qualitative and quantitative methods, especially immunochemistry, further research might reveal bio-signatures of individual patients and respective malignant diseases, leading to individualized treatment approach, according to the concepts of modern integrative medicine.
Keywords
HMDBOPAGSSGLC-MSCysHNEGPXGSHGCsPPPNADPHESCCMOC4-hydroxynonenalG6PEOC2ABDESIMALDI-IMSNIMSnuclear magnetic resonanceGC-MSCE-MSHCCROSCapillary electrophoresis-mass spectrometry2-aminobutyric acidOphthalmic acidImmunochemistryNMROxidative stressKYNKEGG یا Kyoto Encyclopedia of Genes and Genomes Kyoto Encyclopedia of Genes and GenomesCancerCarcinogenesisliver cirrhosisCysteineSIMSSecondary-ion mass spectrometryLiquid chromatography-mass spectrometryMass spectrometryfumarate hydrataseMetabolomicspentose phosphate pathwayBiomarkersnicotinamide adenine dinucleotide phosphateHBVhepatitis B virushuman metabolome databaseLipid peroxidationEsophageal squamous cell carcinomaHepatocellular carcinomakynurenineGas Chromatography-Mass SpectrometryGluGlutathioneglutathione disulfideglutathione synthetaseglutathione peroxidaseglutamateGlucose 6-phosphateGlyGlycineReactive oxygen speciesdesorption electrospray ionization
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Authors
Luka Andrisic, Danuta Dudzik, Coral Barbas, Lidija Milkovic, Tilman Grune, Neven Zarkovic,