| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8286755 | Redox Biology | 2018 | 12 Pages |
Abstract
Specific endothelial reduction of GSH synthesis increases basal and stimulated ROS levels, reduces phosphorylation of eNOS (Ser 1177) and increases eNOS S-glutathionylation, impairing endothelium-dependent vasodilation and promoting renal fibrosis following UUO.173
Keywords
2,3-dimethoxy-1,4-naphthoquinoneKHsEDRFDMNQtetrahydrobiopterinBH4GCLUUOeNOSGAPDHNACKrebs-Henseleit SolutionMLECSDSN-acetylcysteineROSAChEndothelial dysfunctionAcetylcholineUnilateral ureteral obstructionsodium dodecyl sulphateantioxidant response elementendothelium-derived relaxing factorKidney fibrosisglutamate cysteine ligaseglutamate-cysteine ligasenoradrenalinesodium nitroprussideARESNPGlutathioneglutathione synthetaseglyceraldehyde 3-phosphate dehydrogenase
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Authors
Cristina Espinosa-DÃez, Verónica Miguel, Susana Vallejo, Francisco J. Sánchez, Elena Sandoval, Eva Blanco, Pablo Cannata, Concepción Peiró, Carlos F. Sánchez-Ferrer, Santiago Lamas,