Article ID Journal Published Year Pages File Type
8286809 Redox Biology 2017 9 Pages PDF
Abstract
RITA and 3-MA combination overcome the chemoresistance of head and neck cancer cells. RITA-resistant cancer cells include protective autophagy and p62 overexpression. In contrast, RITA-sensitive cancer cells exhibit low levels of p62-Nrf2 proteins with the progressive degradation of autophagic molecules in response to RITA treatment. The combined treatment of 3-MA and RITA inhibits autophagy and Nrf2 antioxidant pathways, resulting in the death of chemo-resistant cancer cells via increased oxidative stress and DNA damage.
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