Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8286809 | Redox Biology | 2017 | 9 Pages |
Abstract
RITA and 3-MA combination overcome the chemoresistance of head and neck cancer cells. RITA-resistant cancer cells include protective autophagy and p62 overexpression. In contrast, RITA-sensitive cancer cells exhibit low levels of p62-Nrf2 proteins with the progressive degradation of autophagic molecules in response to RITA treatment. The combined treatment of 3-MA and RITA inhibits autophagy and Nrf2 antioxidant pathways, resulting in the death of chemo-resistant cancer cells via increased oxidative stress and DNA damage.
Keywords
HNCATG53-MAp62Nrf2LC3DCF-DAGSH2′,7′-dichlorofluorescein diacetate3-methyladenineshort interfering RNAROSsiRNAAutophagyIHCImmunohistochemistryTerminal deoxynucleotidyl transferase dUTP nick end labelingTUNELRITAHead and neck cancercombination indexMicrophthalmia transcription factorantioxidant response elementsnuclear factor (erythroid-derived 2)-like 2AREmicrotubule-associated protein 1A/1B-light chain 3GlutathioneReactive oxygen species
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Authors
Daiha Shin, Eun Hye Kim, Jaewang Lee, Jong-Lyel Roh,