Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

Article ID	Journal	Published Year	Pages	File Type
8287054	Redox Biology	2017	10 Pages	PDF

Keywords

GPx4 SNAP25 IL-1β PSD95 4-hydroxynonenol GFAP 4-HNE IL-6 Iba-1 cognitive impairment Polyunsaturated fatty acid PUFA interleukin-6 Interleukin-1 beta Alzheimer's disease TAM tamoxifen Neurodegeneration tumor necrosis factor alpha Synaptophysin Syn TNF-α Ferroptosis cerebral cortex Transgenic mice ionized calcium-binding adapter molecule-1 Hippocampus Glial fibrillary acidic protein postsynaptic density protein glutathione peroxidase 4

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Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

Authors

William Sealy Hambright, Rene Solano Fonseca, Liuji Chen, Ren Na, Qitao Ran,