Inhibition of Drp1 protects against senecionine-induced mitochondria-mediated apoptosis in primary hepatocytes and in mice

Article ID	Journal	Published Year	Pages	File Type
8287140	Redox Biology	2017	10 Pages	PDF

Keywords

Mfn1 pJNK ActD Drp1 PFA senecionine VDAC ALT Mdivi-1 DHR HRP GAPDH GSH HSOS CyP PHH MFN2 Jnk TMRM LPS zVAD-fmk MMP Phosphorylated c-Jun N-terminal kinase mitochondrial division inhibitor-1 c-Jun N-terminal kinase opa1 primary human hepatocyte MAPK mitochondrial outer membrane permeabilization ROS optic atrophy 1 Liver injury Alanine aminotransferase pyrrolizidine alkaloids actinomycin D HSEC Terminal deoxynucleotidyl transferase dUTP nick end labeling TUNEL Apoptosis Hepatic sinusoidal endothelial cells Cytochrome P450 lipopolysaccharide MOMP mitofusin 1 mitofusin 2 Mitochondria Electron microscopy PAS Hematoxylin and Eosin paraformaldehyde Mitochondrial membrane potential Horseradish peroxidase dynamin-related protein 1 voltage-dependent anion channel Chloroquine Glutathione Reactive oxygen species

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Ageing

Inhibition of Drp1 protects against senecionine-induced mitochondria-mediated apoptosis in primary hepatocytes and in mice

Authors

Xiao Yang, Hua Wang, Hong-Min Ni, Aizhen Xiong, Zhengtao Wang, Hiromi Sesaki, Wen-Xing Ding, Li Yang,