Synergistic antitumor activity of rapamycin and EF24 via increasing ROS for the treatment of gastric cancer

Article ID	Journal	Published Year	Pages	File Type
8287185	Redox Biology	2016	12 Pages	PDF

Keywords

dichlorodihydrofluorescein CAAT/enhancer binding protein MDA MDM-2 S6 ribosomal protein EF24 2′, 7′-dichlorodihydrofluorescein diacetate c-Jun N terminal kinase mTOR complex mTORC JC-1 PARP Bcl2 eIF2 DCFH-DA HRP Ki-67 Dcf FITC ATF4 NAC Jnk mTOR 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide C/EBP MTT PI3 kinase ROS Oxidative stress CHOP murine double minute 2 Rapamycin Gastric cancer Cytotoxicity endoplasmic reticulum Antitumor eukaryotic initiation factor 2 phosphoinositide 3-kinase activating transcription factor 4 fluorescein isothiocyanate B-cell lymphoma 2 malondialdehyde N-acetyl cysteine mammalian target of rapamycin Horseradish peroxidase protein kinase RNA-like endoplasmic reticulum kinase Propidium iodide PERK poly (ADP-ribose) polymerase Reactive oxygen species

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Synergistic antitumor activity of rapamycin and EF24 via increasing ROS for the treatment of gastric cancer

Authors

Weiqian Chen, Peng Zou, Zhongwei Zhao, Xi Chen, Xiaoxi Fan, Rajamanickam Vinothkumar, Ri Cui, Fazong Wu, Qianqian Zhang, Guang Liang, Jiansong Ji,