Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8287194 | Redox Biology | 2017 | 16 Pages |
Abstract
PKG1 is localized in the tip of the spiky growth cone and is activated by redox-mediated dimerization, or by cGMP, the latter released after stimulation of natriuretic peptide receptors (Npr). Redox signals are generated in the growing tip and trigger growth cone collapse. The redox-evoked collapse involves PKG1-dimerization/autoactivation, subsequent phosphorylation of ADF/cofilin and finally, P-cofilin-mediated actin depolymerization. On collapse PKG1 retracts from the cone and returns on natriuretic peptide mediated attraction. The cycle ensures correct guidance of the growing cone.208
Keywords
EYFPIP3Inositol trisphosphateNF200Gap43NOScGMPOXPHOSSNIATF3SGCSNSDRGNPRCREVASPTRPV1TRPA1ADFROSHydrogen peroxideSpared nerve injuryNerve regenerationTAMtamoxifenSoluble guanylyl cyclasePainRedoxgrowth associated protein 43Slickactin depolymerizing factorIRAKVasodilator-stimulated phosphoproteinActivating transcription factor-3Growth coneSensory NeuronNitric oxidenitric oxide synthaseH2O2enhanced yellow fluorescent proteinCre recombinaseCofilindorsal root gangliaReactive oxygen speciesnatriuretic peptide receptor
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Authors
Lucie Valek, Annett Häussler, Stefan Dröse, Philipp Eaton, Katrin Schröder, Irmgard Tegeder,