Redox-guided axonal regrowth requires cyclic GMP dependent protein kinase 1: Implication for neuropathic pain

PKG1 is localized in the tip of the spiky growth cone and is activated by redox-mediated dimerization, or by cGMP, the latter released after stimulation of natriuretic peptide receptors (Npr). Redox signals are generated in the growing tip and trigger growth cone collapse. The redox-evoked collapse involves PKG1-dimerization/autoactivation, subsequent phosphorylation of ADF/cofilin and finally, P-cofilin-mediated actin depolymerization. On collapse PKG1 retracts from the cone and returns on natriuretic peptide mediated attraction. The cycle ensures correct guidance of the growing cone.208