| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8287216 | Redox Biology | 2017 | 9 Pages |
Abstract
Nrf2 inhibition attenuates artesunate resistance in cisplatin-resistance HNC cells. Artesunate (Arts) selectively kills HNCs but not normal cells via the induction of iron-dependent, ROS-mediated ferroptosis. However, Arts increased Nrf2 expression, which contributed to ferroptosis resistance. Thus, suppression of Nrf2 enhances ferroptosis and causes the death of resistant HNC cells.241
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Authors
Jong-Lyel Roh, Eun Hye Kim, Hyejin Jang, Daiha Shin,