Epigallocatechin-3-gallate enhances key enzymatic activities of hepatic thioredoxin and glutathione systems in selenium-optimal mice but activates hepatic Nrf2 responses in selenium-deficient mice

Article ID	Journal	Published Year	Pages	File Type
8287258	Redox Biology	2016	12 Pages	PDF

Keywords

BSO GAPDH RT-PCR GSSG ALT UPLC Epigallocatechin-3-gallate RNS CDNB IL-10 ECL IL-2 RIPA TBS-T γ-H2AX Trx TrxR NQO1 RPS6 forkhead box class O PRX GRx phosphorylated histone 2AX SELP Sp1/Sp3 HO1 Tris-buffered saline with 0.05% Tween 20 PBS qPCR GPX PVDF SDS 4-HNE Nrf2 SEC GSH GST IL-6 4-hydroxynonenal EGCG 1-chloro-2, 4-dinitrobenzene keap1 NAD(P)H:quinone oxidoreductase 1 ROS Hydrogen peroxide AST Aspartate aminotransferase Alanine aminotransferase EDTA ethylene diamine tetraacetic acid Interleukin-10 interleukin-6 Interleukin-2 buthionine sulfoximine thioredoxin reductase thioredoxin Room temperature SOD sodium dodecyl sulfate Selenocysteine Selenoprotein P Selenium Triple quadrupole mass spectrometer Superoxide dismutase Thioredoxin system Glutathione system nuclear factor erythroid 2-related factor 2 FoxO phosphate buffer solution nicotinamide-adenine dinucleotide phosphate heme oxygenase 1 H2O2 reverse transcriptase polymerase chain reaction quantitative polymerase chain reaction Ribosomal protein S6 Kelch-like ECH-associated protein 1 Peroxiredoxin Polyvinylidene fluoride Ultra-high performance liquid chromatography Glutathione glutathione S-transferase oxidized glutathione glutathione reductase glutathione peroxidase Glutaredoxin glyceraldehyde 3-phosphate dehydrogenase reactive nitrogen species Reactive oxygen species

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Epigallocatechin-3-gallate enhances key enzymatic activities of hepatic thioredoxin and glutathione systems in selenium-optimal mice but activates hepatic Nrf2 responses in selenium-deficient mice

Authors

Ruixia Dong, Dongxu Wang, Xiaoxiao Wang, Ke Zhang, Pingping Chen, Chung S. Yang, Jinsong Zhang,