Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8287325 | Redox Biology | 2017 | 25 Pages |
Abstract
The scheme represents three different scenarios that can occur in a yeast cell upon Aβ42-GFP peptide expression. Scenario I: Soluble Aβ42-GFP species that neither form protein inclusions, nor diffuse aggregates, are not dangerous for the cell; Scenario II: Aβ42-GFP species that do not form protein inclusions but form diffuse aggregates, which can cause intracellular oxidative stress, are hazardous for the cell; Scenario III: Aβ42-GFP species that form protein inclusions are not deleterious for the cell, suggesting that the formation of these big aggregates acts as a protective strategy against oxidative stress.
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Authors
Anita Carija, Susanna Navarro, Natalia Sanchez de Groot, Salvador Ventura,