Positron emission tomography-computed tomography and 4-hydroxynonenal-histidine immunohistochemistry reveal differential onset of lipid peroxidation in primary lung cancer and in pulmonary metastasis of remote malignancies

Article ID	Journal	Published Year	Pages	File Type
8287345	Redox Biology	2017	6 Pages	PDF

Abstract

Both PET-CT and HNE-immunohistochemistry reflect the size of the malignant tissue. However, lipid peroxidation of non-malignant lung tissue in the vicinity of cancer is more pronounced in metastatic than in primary malignancies and might represent the mechanism of defense against cancer, as was recently revealed also in case of human liver cancer.

Keywords

LDHA 18F-FDG GSH SPN NADPH Nrf2 iNOS RNS HOCl PET-CT VATS 4-Hydroxynonenal (HNE)4-hydroxynonenal 18-fluorodeoxyglucose 4-HNE Lipid peroxidation (LPO)RalBP1 mAb MMP keap1 ROS Hydrogen peroxide Hypochloric acid inflammation Ozone nitrogen oxide Immunohistochemistry TAM Cell growth regulation positron emission tomography-computed tomography Video-assisted thoracoscopic surgery NSCLC Non-small cell lung cancer inducible nitric oxide synthase nuclear factor erythroid 2-related factor Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)Lactate dehydrogenase A SUV Tumor-associated macrophages Matrix metalloproteinases standardized uptake value Nitrogen dioxide NO2 H2O2 Monoclonal antibodies Kelch-like ECH-associated protein 1 Solitary pulmonary nodule Glutathione reactive nitrogen species Reactive oxygen species