| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8287371 | Redox Biology | 2017 | 9 Pages |
Abstract
Moreover, we observed that Lon protease downregulation is linked to a higher lipofuscinogenesis whereas the application of the mitochondrial-targeted antioxidant mitoTEMPO is able to prevent the accumulation of this protein aggregate.
Keywords
2',7'-dichlorodihydrofluorescein diacetateDNPPINK1CCCPVDACshRNAMdivi-1DNPHFis1MTGSA-β-galsdhAFCCPKi-67OCRDrp-1mitochondrially encoded cytochrome c oxidase IDAPI2,4-DinitrophenylhydrazoneFITCCOX IVMitoTEMPOmitochondrial division inhibitor 1DOXFBSSDSDMEMMT-CO12,4-dinitrophenylhydrazine4′,6-diamidino-2-phenylindole dihydrochlorideDMSOMitochondrial DNADulbecco's modified Eagle MediumH2DCFDAMTTPTEN-induced putative kinase 1RNA interferenceRNAishort hairpin RNAROSsenescence associated β-galactosidaseEDTAEthylenediaminetetraacetic acidprotein aggregatesOxidative stressdoxycyclinemtDNADimethyl sulfoxideelectron transport chainAgingsodium dodecyl sulfatefetal bovine serumcytochrome c oxidase subunit IVSipsEmission wavelengthExcitation wavelengthfluorescein isothiocyanateLipofuscinmethylthiazolyldiphenyl-tetrazolium bromideMitochondriaOxygen consumption rateETcParaquatLon proteasemitochondrial fission 1 proteindynamin-related protein 1Propidium iodideStress-induced premature senescencevoltage-dependent anion channelCarbonyl cyanide 3-chlorophenylhydrazoneCarbonyl cyanide 4-(trifluoromethoxy) phenylhydrazoneReactive oxygen species
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Authors
Jeannette König, Christiane Ott, MartÃn Hugo, Tobias Jung, Anne-Laure Bulteau, Tilman Grune, Annika Höhn,