| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8368207 | Advances in Medical Sciences | 2018 | 8 Pages |
Abstract
Extended research is necessary for the development of these novel compounds targeting the eicosanoid pathway, by increasing the levels of anti-inflammatory eicosanoids (PGD2,15dPGJ2), by inhibiting the production of pro-inflammatory eicosanoids (PGE2, LTB4, PGI2) involved in rheumatoid arthritis or also by developing dual compounds displaying both the COX-2 inhibitor/TP antagonist activity within a single compound.
Keywords
IFN-γ12-lipoxygenasePGE2PGH2FLSDMARDsmPGESpgdsRheumatoid arthritis synovial fibroblastsH-PGDS12-LOXGPCRAP-115-LOPLA2LTB4PPAR-γTh17ACPAEETsCysLTMMPPGF2α5-LOT helper 17IL-6PGI2IL-1cPGESPGESNSAIDCOX-2 selective inhibitorsEULARNFkBPGD2Cysteinyl leukotrienes15d-PGJ2PlGF15-Lipoxygenase5-Lipoxygenase8-iso-PGF2α8-iso-prostaglandin F2αG-protein coupled receptorsL-PGDSTLRscollagen induced arthritisRheumatoid arthritisTNF alphaanti-citrullinated protein antibodiesphospholipase A2Arachidonic acidepoxyeicosatrienoic acidshydroxyeicosatetraenoic acidsinflammationinterleukin-6interleukin-1Thromboxanestumor necrosis factor alphanon steroidal anti-inflammatory drugsdisease-modifying antirheumatic drugsCIAMIFplacenta growth factorrheumatoid factorMacrophage migration inhibitory factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)nuclear factor kappa-light-chain-enhancer of activated B cellscardiovascularLeukotriene B4LeukotrienesLipoxinsEuropean League Against Rheumatismfibroblast-like synoviocytesMatrix metalloproteinasesArachidonic acid pathwayHETEactivator protein 1prostacyclinProstaglandin D2prostaglandin E synthaseProstaglandin E2Prostaglandin F2αProstaglandin H2ProstaglandinsCoxibInterferon gammaToll-like receptors
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Authors
Malvina Hoxha,