Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8369090 | Biologicals | 2018 | 11 Pages |
Abstract
Main topics of the manuscript include: What factors influence the (Fc) glycan pattern in therapeutic antibodies and how can these glycans be characterized? How does structure of the Fc-glycan relate to function and what methods are available to characterize those functions? Although heterogeneous in their scope, the different sections are intended to combine current knowledge on structure-function correlations of IgG glycan structures with regard to Fc (effector) functions, as well as basic aspects and methodologies for their assessment.
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Authors
Florian Cymer, Hermann Beck, Adelheid Rohde, Dietmar Reusch,