Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8376081 | CMGH Cellular and Molecular Gastroenterology and Hepatology | 2018 | 13 Pages |
Abstract
Every year, enteric infections and associated diarrhea kill millions of people. The situation is compounded by increases in the number of enteric pathogens that are acquiring resistance to antibiotics, as well as (hitherto) a relative paucity of information on host molecular targets that may contribute to diarrhea. Many forms of diarrheal disease depend on the dysregulation of intestinal ion transporters, and an associated imbalance between secretory and absorptive functions of the intestinal epithelium. A number of major transporters have been implicated in the pathogenesis of diarrheal diseases and thus an understanding of their expression, localization, and regulation after infection with various bacteria, viruses, and protozoa likely will prove critical in designing new therapies. This article surveys our understanding of transporters that are modulated by specific pathogens and the mechanism(s) involved, thereby illuminating targets that might be exploited for new therapeutic approaches.
Keywords
NHERF2Clostridium difficile toxinCLCA1NHESGLT1GPR39CXCR2LPANKCCKCCPKCCFTREPECTNFSLCETECCDITCDcAMPDRAENaCEnteropathogenic Escherichia colienterotoxigenic Escherichia coliadenosine 3′,5′-cyclic monophosphateAdenosine TriphosphateATPadenosine triphosphataseDiarrhealysophosphatidic acidATPaseEpitheliumheat-labile toxinsolute carrierion transportOral rehydration therapycystic fibrosis transmembrane conductance regulatorSodium/hydrogen exchangercholera toxinClostridium difficile infectiontumor necrosis factorORTEnteric pathogendown-regulated in adenomaProtein kinase Cepithelial sodium channel
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Authors
Soumita Das, Rashini Jayaratne, Kim E. Barrett,