Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis AreÂ Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)

Article ID	Journal	Published Year	Pages	File Type
8376377	CMGH Cellular and Molecular Gastroenterology and Hepatology	2018	79 Pages	PDF

Keywords

PDI NF-κB α-SMA SREBP-1c ATF4 CAT Nrf2 GSH PTT TGFβ Bcl-2 SHP qRT-PCR GSSG GTT MCP-1 PPARγ Cpt1a NAS SFN cox2 CD36 PPARα GSTM1 IκB AP-1 UPR XBP1 eIF2α ATF6 IKK PARP Heme oxygenase-1 MCD ADRP Kelch-like ECH-associated protein-1 NOS2 apoB HMOX1 FXR NQO1 GCLC ChREBP ACLY ATP citrate lyase COL1A1 SCD1 stearoyl-CoA desaturase-1 DGAT2 MTTP Jnk1 Acox2 LXRα GCLM ACACA CDDO quantitative reverse transcriptase PCR PTGR1 SLC7A11 PRDX6 GPx2 NAFLD Txnrd1 eukaryotic translation initiation factor 2A gsta4 NF-E2 p45-related factor 2 c-Jun N-terminal kinase 1 P58IPK BiP keap1 C/EBP MPO DMSO farnesoid X receptor H&E IκB kinase IRE1α NAD(P)H:quinone oxidoreductase 1 insulin tolerance test pyruvate tolerance test alpha smooth muscle actin Apolipoprotein B short-chain acyl-CoA dehydrogenase nonalcoholic steatohepatitis acetyl-CoA carboxylase alpha fatty acid synthase ITT non-alcoholic fatty liver disease Transforming growth factor beta-1 glucose tolerance test tumor necrosis factor-α CHOP Thioredoxin reductase-1 Thioredoxin-1 X-box binding protein-1 cluster of differentiation 36 Dimethyl sulfoxide Sulforaphane Cyclooxygenase-2 endoplasmic reticulum small heterodimer partner TNF-α nuclear factor-κB Fasn activating transcription factor-4 activating transcription factor-6 B-cell lymphoma methionine- and choline-deficient inhibitor of NF-κB myeloperoxidase NAFLD activity score Nash Nitric oxide synthase-2 Hematoxylin and Eosin polymerase chain reaction PCR Unfolded protein response CCAAT/enhancer-binding protein Monocyte chemotactic protein-1 microsomal triglyceride transfer protein Binding immunoglobulin Protein protein disulfide isomerase activator protein 1 adipose differentiation-related protein sterol regulatory element-binding protein-1c PERK peroxiredoxin 6 poly ADP ribose polymerase high-fat Catalase carnitine palmitoyltransferase 1a Scad reduced glutathione liver X receptor α carbohydrate-responsive element-binding protein oxidized glutathione peroxisome proliferator-activated receptor γ peroxisome proliferator-activated receptor α

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry, Genetics and Molecular Biology (General)

Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis AreÂ Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)

Authors

Ritu S. Sharma, David J. Harrison, Dorothy Kisielewski, Diane M. Cassidy, Alison D. McNeilly, Jennifer R. Gallagher, Shaun V. Walsh, Tadashi Honda, Rory J. McCrimmon, Albena T. Dinkova-Kostova, Michael L.J. Ashford, John F. Dillon, John D. Hayes,