Seeing is understanding: Salmonella's way to penetrate the intestinal epithelium

Article ID	Journal	Published Year	Pages	File Type
8385020	International Journal of Medical Microbiology	2018	10 Pages	PDF

Abstract

The molecular processes that govern host-microbial interaction illustrate not only the sophisticated and multifaceted mechanisms that protect the host from infection, but also the elaborated features of microbial pathogens that have evolved to overcome or evade the host's immune system. Here we focus on Salmonella that like other enteric pathogens must overcome the intestinal mucosal immune system, a surface constantly on alert and evolved to restrict the enteric microbiota. We discuss the initial step of Salmonella infection, the penetration of the intestinal epithelial barrier and the models used to study this fascinating aspect of microbial pathogenesis.

Keywords

TRAF receptor activator of nuclear factor kappa-B ETs WRC p.i.T3SS Lgr Rac1 FAE TLR WASP Nlrp PKC GEF Wnt GTPase SAA PMN CDC42 SIP UEA CFU WAVE regulatory complex NOD homologous to the E6-AP carboxyl terminus E26 transformation-specific NLRC EGF ARNO SPI SOP NF-κB GPX SCV RANKL HECT MAPK Mitogen activated protein kinases ROS sIgA ulex europaeus agglutinin STAT Intestinal epithelium Mucosal immunology interleukin Secretory IgA Salmonella pathogenicity island nucleotide-binding oligomerization domain lethal dose Rank Ras-related C3 botulinum toxin substrate 1 Salmonella wingless-related integration site M cell Polymorphonuclear cell type 3 secretion system Epithelial growth factor post infection Guanine-nucleotide exchange factor nuclear factor kappa-light-chain-enhancer of activated B cells LAMP Signal transducer and activator of transcription Infection model BMP Wave NAIP Hepoxilin Salmonella-containing vacuole Microbial pathogenesis serum amyloid protein Wiskott-Aldrich syndrome protein lysosomal-associated membrane protein Neuronal apoptosis inhibitory protein Bone morphogenetic protein cell division control protein 42 homolog Protein kinase C colony forming unit glutathione peroxidase Glycoprotein Reactive oxygen species Toll-like receptors receptor activator of nuclear factor kappa-B ligand