Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8385191 | International Journal of Medical Microbiology | 2015 | 12 Pages |
Abstract
Platelets attenuated hyphal elongation and viability of A. fumigatus and in total 584 differentially expressed genes were identified, many of which were associated with regulation of biological processes, stress response, transport and metabolism. FunCat and KEGG enrichment analyses showed stress response and metabolic adaptation to be increased in response to platelets. Our findings demonstrate that A. fumigatus displayed a specific transcriptional response when exposed to platelets, thus reflecting their antifungal activities.
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Authors
Susanne Perkhofer, Christoph Zenzmaier, Emilie Frealle, Michael Blatzer, Hubert Hackl, Bettina Sartori, Cornelia Lass-Flörl,