| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8385264 | International Journal of Medical Microbiology | 2015 | 9 Pages |
Abstract
In this review, we focus on the global as well as more specific contribution of YopM to virulence of Yersinia during infection and point out the various extra- and intracellular molecular functions of YopM. In addition, the novel cell-penetrating ability of recombinant YopM and its potential applications as a self-delivering immunomodulatory therapeutic will be discussed.
Keywords
PMNYersinia outer proteinribosomal S6 protein kinaseRSKYopMT3SSLRRMLNPRKEGR1NLSCPPCPEIDCNEMOPTDMAPKinterferonIFNinterleukintumor necrosis factor αleucine-rich repeatProtein transduction domainNELNK cellsNatural killer cellsPro-inflammatory cytokinestype 3 secretion systemnuclear localization signalAnti-inflammatoryInfectionTNF-αpolymorphonuclear leukocyteNF-κB essential modulatormitogen-activated protein kinasemesenteric lymph nodeYop
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Authors
Sabrina Höfling, Benjamin Grabowski, Stefanie Norkowski, M. Alexander Schmidt, Christian Rüter,