Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8385960 | International Journal of Medical Microbiology | 2013 | 4 Pages |
Abstract
Clonal variants of Mycobacterium tuberculosis can emerge as a result of microevolution phenomena. The functional significance of these subtle genetic rearrangements is normally disregarded. We show that clonal variants from two patients had different infective behaviours in some in vitro cellular infection models but not in others. Microevolution may have a subtle impact on infectivity, but specific experimental conditions are needed to unmask it.
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Authors
Yurena Navarro, Laura Pérez-Lago, Fernanda Sislema, Marta Herranz, LucÃa de Juan, Emilio Bouza, DarÃo GarcÃa-de-Viedma,