Idiopathic Premature Ovarian Failure and its association to the abnormal longitudinal changes of telomere length in a population of Iranian Infertile Women: A pilot study

Our findings demonstrate a possible relationship between telomere lengthening and idiopathic POF. The reason of the observed elevated telomeres' genetic material could be explained by numerous probable mechanisms like reduced ovarian cell division rate, a sudden increase in the estrogen level before menopause and after egg depletion, and/or an autoimmune condition which could change the composition of blood cells and their consequent conversion to the cells with longer telomeres in patients. More experiments with larger population are necessary to confirm the results of present study.