| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8388950 | Meta Gene | 2018 | 29 Pages |
Abstract
Quite a few of the genes of the KIR, which are not uncommon in Indian population are also significantly associated with SLE in Indian patients. Few KIR genes can be used as biomarkers to understand the severity of the disease. The KIR genes in this cohort lead to decreased inhibitory signal and increased activation of NK cells and therefore causing increased apoptosis and formation of autoantibodies.
Keywords
KirSLE Disease Activity IndexSLEDAIdouble stranded deoxyribonucleic acidSSPEtBrACRSjogrens syndromenatural killeranti-dsDNA antibodiesds-DNASequence Specific Primeranti-nuclear autoantibodiesethidium bromideUltravioletANACNSWorld Health OrganisationNK cellcentral nervous systemSystemic lupus erythematosusSLEmajor histocompatibility complexMHClupus nephritispolymerase chain reactionPCRSLICCAmerican College of RheumatologySystemic Lupus International Collaborating ClinicsWHO
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Authors
Leenam Dedhia, Vandana Pradhan, Kanjaksha Ghosh, Sunil Parekh,