Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8389020 | Meta Gene | 2018 | 20 Pages |
Abstract
We conducted the current meta-analysis to quantitatively summarize the evidence for the strength of the associations between 4-bp insertion/deletion (I/D) polymorphism (rs10680577) of EGLN2 and cancer risk. Using databases searches, we included 5 case-control studies encompassing 3030 cases and 4728 controls. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. The findings of this meta-analysis highlighted that the 4-bp I/D polymorphism of EGLN2 significantly increased the risk of cancer in codominant, dominant, overdominant, and allele inheritance genetic models in Asian population. However, future case-control studies with large-scale and more ethnicities are required to provide more precise evidence.
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Authors
Mohammad Hashemi, Farhad Tabasi, Hossein Ansari,