Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8394201 | Toxicon | 2018 | 29 Pages |
Abstract
The molecular mechanism of the local hypersensitivity reactions to wasp venom including dermal necrosis remains an enigma regardless of the numerosity of the reported cases. In this study, we discovered a new membrane disrupting toxin, VESCP-M2 responsible for tissue damage symptoms following Vespa mandarinia envenomation. Electrophysiological assays revealed a potent ability of VESCP-M2 to permeate the cell membrane whereas in vivo experiments demonstrated that VESCP-M2 induces edema, pain and dermal necrosis characterized by the presence of morphological and behavioral phenotypes, pro-inflammatory mediators, biomarkers as well as the disruption of dermal tissue. This study presents the molecular mechanism and symptom-related function of VESCP-M2 which may form a basis for prognosis as well as therapeutic interventions.
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Authors
Rose Ombati, Yunfei Wang, Canwei Du, Xiancui Lu, Bowen Li, Atunga Nyachieo, Yaxiong Li, Shilong Yang, Ren Lai,