Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8395498 | Toxicon | 2015 | 5 Pages |
Abstract
TsTX-I, isolated from Tityus serrulatus scorpion venom, causes epileptic-like discharges when injected into the central nervous system. The involvement of excitatory amino acids and cytokines in this activity was investigated. Our results have demonstrated that TsTX-I increases the release of IFN-γ but does not alter the intracerebral concentration of the excitatory amino acids in rats. Thus, this cytokine seems to be more important in the convulsive process than glutamate.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry, Genetics and Molecular Biology (General)
Authors
Renan Volner Rodriguez, Valquiria Abrão Coronado Dorce, Lucas Alves de Freitas, Ana Leticia Coronado Dorce, Ivo Lebrun, Ana Claudia Martins Sobral, Fernanda Calheta Vieira Portaro, Alexandre Kazuo Kuniyoshi, Daniela Cajado Carvalho,