| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8396106 | Toxicon | 2014 | 5 Pages |
Abstract
The anti arthritic and anti inflammatory activity of NN-32, a cytotoxic protein from Indian spectacle cobra snake (Naja naja) venom has been studied in Freund's complete adjuvant (FCA) induced arthritis and carrageenan induced anti inflammatory model. NN-32 treatment showed significant decrease in physical and urinary parameters, serum enzymes, serum cytokines levels as compared to arthritic control group of rats. NN-32 treatment recovered carrageenan induced inflammation as compared to control group of rats. The findings showed that the cytotoxic protein NN-32 shares anti arthritic and anti inflammatory activity and thus NN-32 may target complex pathophysiological processes like cancer- arthritis-inflammation.
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Authors
Antony Gomes, Poulami Datta, Tanaya Das, Ajoy Kumar Biswas, Aparna Gomes,