Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8396764 | Toxicon | 2014 | 6 Pages |
Abstract
In this study, we show that administration of Bothrops moojeni venom in rats induces a general disturbance in the distribution and content of the tight junctional protein ZO-1, the cell-matrix receptor beta 1 integrin, the cytoskeletal proteins, vinculin and F-actin, and of the extracellular matrix component laminin in renal corpuscles and cortical nephron tubules. These findings suggest that cell-cell and cell-matrix adhesion proteins may be molecular targets in the B. moojeni-induced kidney injury.
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Authors
Carla Beatriz Collares-Buzato, Maria Alice da Cruz-Höfling,