| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8397976 | Toxicon | 2013 | 12 Pages |
Abstract
⺠A novel snake venom metalloproteinase, CamVMPII was identified from cDNA library of venom glands of Crotalus adamanteus. ⺠The disintegrin domain (r-Cam-dis) of CamVMPII is expressed in Escherichia coli. ⺠r-Cam-dis inhibits platelet adhesion, platelet aggregation, and platelet function on clot retraction. ⺠r-Cam-dis is a potent anti-platelet inhibitor.
Keywords
Crotalus adamanteusIPTGACTADPPrPcDNAadenosine diphosphatecomplementary deoxyribonucleic acidsodium dodecyl sulfate-polyacrylamide gel electrophoresisSDS-PAGERGD motifisopropyl β-d-thiogalactosiderapid amplification of cDNA endsactivated clotting timeplatelet functionDisintegrinplatelet activitySnake venom metalloproteinaseRaceUTR یا untranslated regions untranslated regionIsoelectric pointpolymerase chain reactionPCRplatelet-rich plasmacDNA library
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Authors
Montamas Suntravat, Ying Jia, Sara E. Lucena, Elda E. Sánchez, John C. Pérez,