| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8398098 | Toxicon | 2013 | 8 Pages |
Abstract
⺠JZTX-I docked at the voltage sensor paddle of Kv2.1. ⺠JZTX-I inhibited Kv2.1 channel activation by trapping voltage sensor in the resting state. ⺠Four residues (I273, F274, E277, and K280) in the paddle motif of Kv2.1 were crucial determinants for JZTX-I binding.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry, Genetics and Molecular Biology (General)
Authors
Huai Tao, Yuanyuan Wu, Meichun Deng, Juan He, Meichi Wang, Yucheng Xiao, Songping Liang,