| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8398419 | Toxicon | 2011 | 8 Pages |
Abstract
⺠Monocrotaline causes hepatotoxicity in animals and humans. ⺠Its metabolite dehydromonocrotaline has been reported as responsible by the toxicity. ⺠Only dehydromonocrotaline inhibited the mitochondrial complex I-linked respiration. ⺠Monocrotaline caused cellular death by apoptosis after its metabolism stimulation. ⺠Fructose or dithiotreitol prevented the toxic effect of monocrotaline on hepatocytes.
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Authors
Marcos A. Maioli, Larissa C. Alves, Diego Perandin, Andréa F. Garcia, Flávia T.V. Pereira, Fábio E. Mingatto,