Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8398827 | Mitochondrion | 2018 | 12 Pages |
Abstract
In literature there are no data related to mitochondrial DNA (mtDNA) content in sudden intrauterine unexplained death syndrome (SIUDS). To test the hypothesis that a quantitative excess of mtDNA could play a role in the pathogenesis of SIUDS, mtDNA content was measured in cerebral cortex of 9 SIUDS and in 7 controls. The median (interquartile range) mtDNA in SIUDS and controls was 14,000 (8600-33,500), 3400 (0-8500) copies per nuclear DNA, respectively (p = 0.007). If mitochondria are involved in SIUDS, then higher mitochondrial DNA content may be a biomarker of this syndrome.
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Authors
Lattuada D., Alfonsi G., Roncati L., Pusiol T., Bulfoni A., Ferrero S., Lavezzi A.M.,