Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8398838 | Mitochondrion | 2018 | 7 Pages |
Abstract
Mitochondrial genetic variation with resultant alterations in oxidative phosphorylation may influence vascular function and contribute to cardiovascular disease susceptibility. We assessed relations of peptide-encoding variants in the mitochondrial genome with measures of vascular function in Framingham Heart Study participants. Of 258 variants assessed, 40 were predicted to have functional consequences by bioinformatics programs. A maternal pattern of heritability was estimated to contribute to the variability of aortic stiffness. A putative association with a microvascular function measure was identified that requires replication. The methods we have developed can be applied to assess the relations of mitochondrial genetic variation to other phenotypes.
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Authors
Jessica L. Fetterman, Chunyu Liu, Gary F. Mitchell, Ramachandran S. Vasan, Emelia J. Benjamin, Joseph A. Vita, Naomi M. Hamburg, Daniel Levy,