| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8398853 | Mitochondrion | 2018 | 13 Pages |
Abstract
The increased functionality of liver cell lines upon AMC-BAL culturing is associated with increased mitochondrial biogenesis. High oxygenation, medium perfusion and 3D configuration contribute to the up-regulation of the mitochondrial biogenesis.
Keywords
MT-ND5C3aMT-ATP6HepaRGMDR1CYP3A4N-acetyl transferasemt-ND1BALAmCELADMMPACpt1aNATABCA12CEBPAOXPHOSACO2MT-CO3FDR2 dimensional3 DimensionalCCAAT/enhancer-binding protein alphaROSMitochondrial biogenesisCitrate synthasecytochrome P450 3A4Oxidative phosphorylationfalse discovery rateNADnicotinamide adenine dinucleotideGene ontologyHepatocyteTCA cyclecarnitine palmitoyltransferase 1abio-artificial liverReactive oxygen species
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Authors
Aziza A.A. Adam, Martien van Wenum, Vincent A. van der Mark, Aldo Jongejan, Perry D. Moerland, Riekelt H. Houtkooper, Ronald J.A. Wanders, Ronald P. Oude Elferink, Robert A.F.M. Chamuleau, Ruurdtje Hoekstra,