| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8399105 | Mitochondrion | 2016 | 5 Pages |
Abstract
Our findings demonstrate that dopaminergic neurons of the substantia nigra are specifically vulnerable to defective mtDNA replication/repair or quality control and not to primary point mutations of mtDNA. These results support the hypothesis that accumulating somatic mtDNA damage plays an important role in neurodegeneration.
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Authors
Charalampos Tzoulis, Thomas Schwarzlmüller, Martin Biermann, Kristoffer Haugarvoll, Laurence A. Bindoff,