Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8399110 | Mitochondrion | 2016 | 12 Pages |
Abstract
Rg1 through modulation of GDH and MFN2 maintained mitochondrial dynamics that resulted in protection against H/R-induced cardiomyocyte injury. All these results put forward a new protective mechanism of Rg1 on the therapeutic potential in cardiac I/R disorders.
Keywords
KRbMfn1Ginsenoside Rg1OCRDrp1ECARMFN2GDHα-KGopa1H/RI/RROSoptic atrophy 1α-Ketoglutaric acidischemia/reperfusionMitochondrial dynamicslactate dehydrogenaseLDHmitofusin 1mitofusin 2Oxygen consumption rateextracellular acidification ratehypoxia/reoxygenationdynamin-related protein 1Creatine kinaseKrebs–Ringer bicarbonateglutamate dehydrogenaseReactive oxygen species
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biophysics
Authors
Gengting Dong, Tingbo Chen, Xuecong Ren, Zhifeng Zhang, Weixue Huang, Liang Liu, Pei Luo, Hua Zhou,