| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8399110 | Mitochondrion | 2016 | 12 Pages |
Abstract
Rg1 through modulation of GDH and MFN2 maintained mitochondrial dynamics that resulted in protection against H/R-induced cardiomyocyte injury. All these results put forward a new protective mechanism of Rg1 on the therapeutic potential in cardiac I/R disorders.
Keywords
KRbMfn1Ginsenoside Rg1OCRDrp1ECARMFN2GDHα-KGopa1H/RI/RROSoptic atrophy 1α-Ketoglutaric acidischemia/reperfusionMitochondrial dynamicslactate dehydrogenaseLDHmitofusin 1mitofusin 2Oxygen consumption rateextracellular acidification ratehypoxia/reoxygenationdynamin-related protein 1Creatine kinaseKrebs–Ringer bicarbonateglutamate dehydrogenaseReactive oxygen species
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Authors
Gengting Dong, Tingbo Chen, Xuecong Ren, Zhifeng Zhang, Weixue Huang, Liang Liu, Pei Luo, Hua Zhou,